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dermamelan® intimate

depigmenting solution

Anti-aging depigmentation method that provides a corrective, regulating action, achieving an effective result in the short and long term to correct hyperpigmentation of: genital-perineal area, perianal area, mons pubis, inner thighs and groins.Results visible in a single clinical session.

The problem: intimate hyperpigmentation.

Gynaeco-aesthetic treatments have experienced a growing worldwide demand and have become one of the fastest growing disciplines, due to women searching for solutions to correct imperfections in the intimate area.

Intimate hyperpigmentation is a growing concern. The negative impact on the patient's physical and psycho-emotional well-being is leading to increasing consultations in daily gynaecological practice.

Pigmentation in the intimate area is multifactorial in origin: the ageing of tissue, a genetic predisposition and external factors, such as rubbing of the skin, depilation, wearing tight clothing and hormonal changes (due to using contraceptives, pregnancy, etc.), can cause the intimate area to darken.

dermamelan® the depigmentation solution for the intimate area

mesoestetic® shows a unique method to correct, in a single clinical session, pigmentation imperfections and improve the quality, turgor and appearance of the intimate area specifically formulated to be effective and respect the characteristics of the skin in that area.

dermamelan® intimate is the anti-aging depigmentation method that provides a corrective, regulating action, achieving an effective result in the short and long term to correct hyperpigmentation of:

> genital-perineal area

> perianal area

> mons pubis

> inner thighs and groins

The new dermamelan® method contains a unique combination of active ingredients with a depigmenting efficacy combined with an action on the inflammatory component characterising many hyperpigmentations and a visible improvement in skin quality, turgor and water-retention in the area:

[meso] intimate system® exclusively developed by mesoestetic® combines 6 innovative active ingredients with complementary synergistic action. Its lastgeneration liposome encapsulation system provides maximum efficacy

[GL] Inflamm® contributes to controlling the effects of the inflammatory condition, enhances progressive depigmentation and promotes the defence mechanisms to recover skin balance reducing hypersensitivity reactions.

dermamelan® intimate: results

results in vivo

Clinical efficacy studies support the success of the treatments in all types of skin and types of hyperpigmentations.Visible results in a single session.

results in vitro


The ability of [meso] intimate system® to inhibit melanin production has been evaluated inmelanocyte cultures:

[meso] intimate system® evidences its efficacy in the inhibition of melanin synthesis. After 48h of exposure to [meso] intimate system® melanin levels return to baseline.

intimate 1


The anti-inflammatory capacity of [GL] Inflamm® has been evaluated by measuring the IL-6 marker in a melanocyte culture.

[GL] Inflamm® evidences its efficacy regulating IL-6, a cytokine with pro-inflammatory activity.

After 48h of exposure to [GL] Inflamm® the release of inflammatory agents decreases by 88%.

intimate 2


The vehiculation capacity of the liposomal active ingredients has been evaluated, comparing their increased penetration in the horny and basal layer.

The liposomal active ingredient shows a concentration up to 8 times greater in the innermost layer of the epidermis, the target layer of the active ingredient where it has beneficial effects on the cells.

intimate 3