Its unique and innovative formula safely and efficiently removes existing spots and prevents

specialists in depigmentation

At mesoestetic®, we are depigmentation experts. More than 30 years of research in this field and the experience of thousands of patients around the world make us the reference company.

innovation endorsed by two patents

Our knowledge and the use new technologies in this development has led us to submitting two new patents that endorse the uniqueness of dermamelan®.

excellent clinical results

Tested on all types of spots, dermamelan® has shown high efficacy and safety in all types of skin spots.

high satisfaction from the patient

A progressive treatment that provides visible results from the first weeks and maintains the skin's uniformity and quality in the long term.

dermamelan® experiences and clinical cases

Our patients' results are the best proof of its effectiveness

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What is the dermamelan® method and how does it work?

dermamelan® is the medical depigmenting method that efficiently and progressively eliminates spots by acting on the accumulation of pigment in the skin and on the root of the problem, providing a comprehensive and long-lasting outcome.

The treatment consists in a first session in consultation and a home treatment that lasts 4 months.

in consultation phase. Following a proper diagnosis, the treatment begins with a first session in the medical consultation. The professional applies two masks with an intensive depigmenting action.

at home phase. Continue the treatment following a home guideline. It consists in applying complementary cosmetic products for 4 months with a continuous depigmenting action and long-term regulation of pigment overproduction.

*It is essential to perform the treatment at an authorised centre and to have a professional's follow-up to ensure the authenticity, efficacy and safety of the treatment.


would you like to find out more about skin spots?

Skin spots are a very common problem, especially in women. It involves the darkening of the skin caused by an overproduction of pigment or melanin that unevenly accumulates in the skin. This overproduction is caused by an alteration of certain cellular mechanisms that lead to an excess of pigment.

There are different types of spots based on their origin and their distribution on the skin. It can appear due to several triggering factors, the most important being the result of solar radiation without protection. Other factors are also involved, such as a genetic predisposition, inflammatory conditions, hormonal changes and some photosensitising drugs (oral contraceptives, anti-inflammatory drugs, antibiotics, etc.).

It is a complex problem, and in many cases they are resistant to many medical-aesthetic treatments. In order to achieve an effective and long-lasting outcome and prevent a rebound, we must not only work on eliminating the accumulated pigment that causes the visible darkening, but also on treating the pathology's cellular origin, with the aim of stopping the overproduction of melanin and thus preventing the spots from reappearing.

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  • dermamelan® medical depigmenting treatment

    World's top medical depigmentation treatment. Its unique and innovative formula safely and efficiently removes existing spots and prevents their reappearance, maintaining them under control for a long-lasting outcome.


    medical depigmenting treatment


    Treatment area face
    Type of skin all
    View product
  • dermamelan® treatment

    dermamelan treatment is a home cream whose main action is the attenuation and control of acquired skin pigmentation imperfections of melanic origin, located on the face. 




    Treatment area face
    Type of skin all
    format 30 g
    View product | £199.96

FAQs dermamelan®

How do I know if this treatment is for me?

Suitability of the use of dermamelan® for you can be discussed with your chosen medical specialist during your consultation.

Is it a completely painless treatment?

It is a process in which the skin is completely renewed gradually and on a controlled basis. During the initial phase and after treatment at the clinic, the skin appears reddened and you can feel warmth, but these are mild, expected reactions that will disappear after 24-48 hours. During the home phase, it is normal to experience a slight flaking and sometimes some sensitivity can be felt. These effects disappear with the application of the home products recommended by your specialist.

Is it a treatment compatible with my daily activities?

dermamelan® is a non-invasive topical treatment and does not prevent you following a normal life. It is however vitally important that the daily homecare regime is maintained and sun exposure Will need to be avoided as far as possible.

Will spots disappear completely and forever?

Spots will be very significantly reduced following the treatment however where there has been a spot there will always be a trend for reappearance. It is essential to follow your homecare routine and to constantly use specific photoprotection that prevents repigmentation. Your skin specialist will be able to advise you on the best products for you.

What is the best time of year to perform the treatment?

To obtain the best possible result, the best time is after the summer season, to avoid direct, intense sun radiation during the treatment. In some areas where radiation is unavoidable, it is recommended to avoid direct exposure, the use of a hat and adequate specific photoprotection.

What are the advantages vs other depigmentation treatments?

Other treatments such as laser or peel have a corrective action on the spots, by removing the pigment accumulated in the skin, but their reappearance cannot be avoided. dermamelan® has a dual corrective, but also regulating action to treat the origin of the problem and maintain pigment overproduction under control to prevent recurrence.

What are the side effects of dermamelan®?

If used correctly and under the supervision of a professional, there should be no side effects. dermamelan® is a topical treatment and, therefore, minimally invasive; it does not prevent you from following your normal daily life. During the initial phase and following the treatment in consultation, the skin may become irritated or show redness. This is totally normal and expected, and it will disappear within a few days. During the home phase, it is common to experience slight peeling and sensitivity, which are symptoms that disappear when applying the home products recommended by the specialist.

When can we see the results of dermamelan®?

The most significant change occurs within a few weeks from applying the mask in consultation. We will see an improvement in the skin texture and a reduction of the spot's colour. This is because, during that period, melanin is removed from the outer layers of the skin. However, we must continue with the treatment for the full 4 months, since removing the accumulated melanin is not enough; we need to regulate its overproduction.

What are the ingredients in dermamelan®?

The new dermamelan® formula is an unprecedented formula with two exclusive patents developed by mesoestetic® to achieve maximum efficacy in correcting and regulating hyperpigmentation. They allow for a highly effective and comprehensive action when treating the most resistant spots:

(Syn)pigmentarget: a complex with 3 active ingredients that synergistically act on inhibiting the process of regulating pigment synthesis.

Melaphennone: it acts directly by reducing the overproduction of pigment in the melanocyte (cell responsible for melanin synthesis).

locate your reference centre

Where can I obtain information or undergo the treatment?