option image


the world’s leading medical-aesthetic depigmenting method

dermamelan® is a medical depigmentation method of proven efficacy for the treatment of the most severe, resistant skin hyperpigmentations. Its dual action allows to correct visible hyperpigmentations and regulate melanin overproduction, to provide a short and long-term result.

Multiple clinical studies and thousands of patients and specialists all over the world support the efficacy and safety of dermamelan® for the treatment of all types of skin hyperpigmentations and phototypes.


Skin hyperpigmentation is a common problem that is not influenced by skin type or colour and is triggered by numerous internal and external factors:

• Genetic predisposition

• Sun exposure

• Inflammation

• Hormonal changes

• Aging

• Exposure to chemicals

• Photosensitising medication

Depending on the shape, intensity, tone, site, triggers and resistance to treatment, we can differentiate between various types of dark spots:


Related to hormonal changes occurring in pregnancy and the menopause, or to contraceptive methods or hormone replacement therapy.

Localized. Cheeks, cheekbones, forehead and chin

post-inflammatory hyperpigmentation (PIH)

Following inflammatory processes involving an injury, eruption or burn. Frequently after acne, hair removal and aggressive treatments. Higher risk in dark skin.

Localized. Face and body.

Ephelides (freckles)

Typical in fair skin, with a strong genetic component. They darken when directly exposed to solar radiation.

Localized. Face and body.

Senile or solar lentigos

Appear following occasional or cumulative overexposure to sunlight, and especially with age, in areas exposed to the sun.

Localized. Face, back of hands, cleavage.

The dermamelan® method

dermamelan® is the depigmenting method that provides an intensive corrective action on skin hyperpigmentations while regulating melanin overproduction in melanocytes, inhibiting and controlling reappearance of new spots. It acts at two levels, corrective and regulatory, achieving a short and long-term result to maintain hyperpigmentations under control.

The dermamelan® method consists of a protocol comprising 4 phases which are necessary to achieve the target outcome. Intensive depigmentation in office in phase 1 and treatment for home use in phases 2, 3 and 4.

action of dermamelan®

dermamelan® formula has a unique combination of active ingredients of proven efficacy, 1-6 that act on all phases of the hyperpigmentation process to remove totally the existing hyperpigmentations and prevent their reappearance, as well as the appearance of new spots.


It speeds up the skin renewal process, forcing shedding and removing effectively melanin deposits. Reduces the amount of melanin formed, thus decreasing the intensity of the spot.


It blocks melanosome transfer to keratinocytes to prevent melanin migration to the outermost skin layers.Reduces the activation of tyrosinase, as it contains copper (Cu2+) chelating active ingredients. Reduces the oxidising reactions of tyrosine, neutralising free radicals. Inhibits the tyrosinase enzyme, neutralising its action. This dual corrective and regulating action makes it a unique, all-round treatment.


Before Before
Reduction of hyperpigmentation and improvement of the texture and appearance of the skin. Melasma (phototype I-III)
Before Before
Reduction of hyperpigmentation and improvement of the texture and appearance of the skin. Melasma (phototype I-III)